| ท loss Message Boards ท Alternative Medicine Close Find a Drug Advanced Search ท ซ previous ท 1 ท 2 ท 3 ท 4 ท 5 ท 6 ท 7 ท next ป Paxil-CR Indications & Dosage font size A A A INDICATIONS Major Depressive Disorder: PAXIL CR is indicated for term the treatment of major depressive disorder. The efficacy of PAXIL CR in the treatment of a major depressive episode was established in two 12-week controlled of outpatients whose diagnoses corresponded to the DSM-IV category of major dosage depressive disorder (see CLINICAL PHARMACOLOGY— CLINICAL TRIALS). A major depressive episode (DSM-IV) implies a prominent and relatively persistent (nearly every day for at least 2 weeks) depressed mood or loss of interest or pleasure in nearly all activities, representing a change from previous functioning, and includes the presence of at least 5 of the following 9 symptoms during the same 2-week period: Depressed mood, markedly diminished interest prescription or pleasure in usual activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, brand feelings review of guilt or worthlessness, slowed thinking or impaired concentration, a suicide attempt, or suicidal ideation. The antidepressant action of paroxetine in hospitalized depressed patients has not been adequately studied. PAXIL CR has not been systematically evaluated beyond 12 weeks in controlled clinical trials; however, the effectiveness of immediate-release paroxetine hydrochloride in maintaining a response pfizer in major depressive disorder for up to 1 year has been demonstrated in a placebo-controlled trial (see CLINICAL description PHARMACOLOGY— CLINICAL TRIALS). The pills physician who elects to use PAXIL CR for extended periods should periodically re-evaluate the facts long-term usefulness of the drug for the individual patient. Panic Disorder: PAXIL effectiveness CR is indicated for the treatment of panic disorder, with or without agoraphobia, as defined in DSM-IV. Panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks. work The efficacy of PAXIL CR controlled-release tablets was established in two 10-week trials in panic disorder patients whose diagnoses corresponded to the DSM-IV category of panic disorder (see CLINICAL PHARMACOLOGY— CLINICAL TRIALS). Panic disorder (DSM-IV) is characterized by recurrent unexpected panic attacks, i.e., a discrete period of intense fear or discomfort news in which 4 (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: (1) palpitations, pounding heart, or accelerated heart rate; (2) sweating; (3) trembling or shaking; (4) sensations of shortness of breath or smothering; (5) feeling of choking; (6) chest pain or discomfort; (7) nausea or abdominal distress; (8) feeling dizzy, unsteady, lightheaded, or faint; tablet (9) derealization (feelings of unreality) or depersonalization (being detached from oneself); (10) fear of losing control; (11) fear of dying; (12) paresthesias (numbness or tingling stories sensations); (13) chills or hot flushes. Long-term maintenance of efficacy with drugs the immediate-release formulation of paroxetine was demonstrated in a 3-month relapse prevention trial. In this trial, patients with panic disorder assigned to immediate-release paroxetine demonstrated a lower relapse rate compared to patients on placebo (see CLINICAL PHARMACOLOGY— CLINICAL TRIALS). Nevertheless, the physician who prescribes PAXIL CR for extended periods should periodically re-evaluate the long-term usefulness sale of the drug for the individual patient. Social Anxiety Disorder: PAXIL CR is indicated for the treatment of social anxiety disorder, also known as social phobia, as testing in DSM-IV (300.23). Social anxiety disorder is characterized by a marked and persistent fear of 1 or more social or performance situations in which the person is exposed to unfamiliar people or to possible scrutiny by others. Exposure to the feared situation almost invariably provokes story anxiety, which may approach the intensity shipping of a panic attack. The feared situations are avoided or endured with intense anxiety or distress. The avoidance, anxious anticipation, or distress in the feared situation(s) interferes significantly with the person's normal routine, occupational or functioning, or social activities for or relationships, or there is marked distress about having the phobias. Lesser degrees of performance anxiety or shyness generally do not require psychopharmacological treatment. The efficacy of PAXIL CR as a treatment for social anxiety cheap disorder has been established, in part, on the basis long of extrapolation from the established effectiveness of the immediate-release formulation of paroxetine. In addition, the efficacy of PAXIL CR was established in a 12-week trial, in adult outpatients information with social anxiety disorder (DSM-IV). PAXIL CR has not been studied in children or adolescents with social phobia (see CLINICAL PHARMACOLOGY— CLINICAL TRIALS). The effectiveness of PAXIL erection CR in long-term treatment of social anxiety disorder, i.e., for more than 12 weeks, has not been systematically evaluated in adequate and well-controlled trials. Therefore, the physician who elects to prescribe PAXIL CR extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient (see DOSAGE AND ADMINISTRATION). .html'>cheap paxil Premenstrual Dysphoric Disorder: side PAXIL CR is indicated for the treatment of PMDD. The of PAXIL CR in the treatment of PMDD has been established in 3 placebo-controlled uk trials (see CLINICAL PHARMACOLOGY— CLINICAL TRIALS). The essential features of PMDD, according to DSM-IV, include markedly depressed mood, anxiety or tension, affective lability, and use persistent anger or irritability. Other without include decreased http://www.apart-carilo.com/paxil-online.html interest in usual activities, difficulty concentrating, effect lack of energy, change in appetite or sleep, and feeling out of control. Physical delivery symptoms associated with PMDD online include breast woman tenderness, name headache, joint and muscle pain, bloating, and weight picture gain. These sample symptoms occur regularly during the luteal phase and remit within a few days following the onset of menses; the disturbance markedly interferes with work or school or with usual social activities and relationships with others. us In making the diagnosis, care should benefits be taken to rule out other cyclical mood disorders that may be exacerbated by treatment with an antidepressant. The effectiveness of PAXIL CR in long-term use, that is, for more than 3 menstrual cycles, has not been systematically evaluated in controlled trials. Therefore, the physician who elects to use PAXIL CR for extended periods should periodically weight re-evaluate the long-term usefulness of discount generic the drug for does the manufacturer individual patient. DOSAGE AND ADMINISTRATION Major Depressive Disorder: Usual Initial Dosage: PAXIL CR should be administered as a single daily dose, worldwide usually in the morning, with or without food. The recommended initial is 25 mg/day. Patients were dosed in a range of 25 mg to 62.5 cheapest non mg/day in the clinical trials demonstrating during the effectiveness of PAXIL CR in the treatment of major depressive disorder. As with all drugs effective in the treatment of major depressive disorder, the full effect may be delayed. Some patients not responding to a 25-mg dose may benefit from dose increases, in 12.5-mg/day increments, up to a maximum of 62.5 mg/day. Dose changes should occur at intervals of at least 1 week. Patients should be cautioned that PAXIL CR should not be chewed or crushed, and should be swallowed whole. Maintenance Therapy: There is no body of evidence available to answer the question of how long the patient treated with PAXIL CR should remain on it. It is generally agreed where that acute episodes of major depressive medicine disorder require several months or longer of sustained info pharmacologic therapy. Whether the dose of an antidepressant needed to induce remission is identical to the dose needed to maintain and/or sustain using euthymia is unknown. success Systematic evaluation of the efficacy of immediate-release paroxetine hydrochloride has shown that efficacy is maintained for periods of up to 1 year pharmacy with doses that averaged about 30 mg, which corresponds to a 37.5-mg dose of PAXIL of CR, based on relative trial bioavailability considerations (see CLINICAL PHARMACOLOGY—Pharmacokinetics). Panic Disorder Usual Initial Dosage: drug PAXIL CR should be administered as a single effectes daily dose, usually in now the morning. Patients should be started on 12.5 mg/day. Dose changes should occur in 12.5-mg/day increments and at intervals of at least 1 week. Patients were dosed in a range of 12.5 to 75 mg/day in the clinical trials demonstrating the effectiveness of PAXIL CR. The maximum dosage should not exceed 75 mg/day. Patients should be cautioned that PAXIL doses CR should not be chewed or crushed, and should be swallowed whole. Maintenance Therapy: on Long-term maintenance of efficacy with the immediate-release formulation of paroxetine was demonstrated in a 3-month relapse prevention trial. In this trial, patients with panic disorder assigned to immediate-release paroxetine demonstrated a lower relapse rate compared to patients on placebo. Panic disorder is a low chronic condition, and it is reasonable to consider continuation for a responding patient. Dosage adjustments should be made to maintain the patient on the lowest effective dosage, and patients should be periodically reassessed to determine vs the need for continued treatment. Social Anxiety Disorder Usual Initial Dosage: PAXIL CR should be administered fedex as a single daily dose, usually in the morning, with or without food. The recommended initial dose is 12.5 mg/day. Patients were medication dosed in a range of 12.5 mg to 37.5 mg/day in in the clinical trial demonstrating the effectiveness ups cod of PAXIL CR in the treatment of social anxiety disorder. If the dose is increased, this should occur at intervals of at least 1 week, in increments of 12.5 mg/day, up to a maximum of 37.5 mg/day. Patients should be cautioned that PAXIL CR duration should not be chewed or crushed, and should be swallowed whole. Maintenance Therapy: There is no body of evidence available to answer the question of how long the patient treated with PAXIL CR should remain on it. Although the efficacy of PAXIL CR beyond 12 weeks of dosing has not been demonstrated in controlled clinical trials, social buy anxiety disorder is recognized as a chronic condition, and it is reasonable to consider continuation of treatment for a responding patient. Dosage adjustments should be made to maintain the patient on the lowest effective dosage, and patients should be periodically reassessed to determine the need overdose for continued treatment. purchase Premenstrual Dysphoric Disorder Usual Initial Dosage: PAXIL CR should be administered as a single daily dose, usually in the morning, get with or without food. PAXIL CR may be administered either daily throughout the menstrual cycle or limited line to the luteal phase of the menstrual cycle, depending on physician assessment. The recommended initial dose is 12.5 mg/day. In clinical trials, both 12.5 mg/day and 25 mg/day were shown to be effective. Dose changes should occur at intervals of at take least 1 week. Patients should be cautioned that test PAXIL CR should not be chewed or crushed, and should be swallowed whole. Maintenance/Continuation Therapy: The effectiveness of PAXIL CR for a period exceeding 3 menstrual cycles has not been systematically evaluated in controlled trials. However, women commonly report that symptoms lowest worsen with age until relieved by the onset of menopause. Therefore, it is reasonable to consider continuation of a responding patient. Patients should be periodically reassessed to determine the need for continued treatment. Special Populations Treatment usage of Pregnant Women During the Third Trimester: Neonates exposed to PAXIL CR and other SSRIs or SNRIs, late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding (see WARNINGS). When treating pregnant addictive women with paroxetine during the third trimester, the alternative physician should carefully consider the potential risks and benefits of treatment. The physician may consider tapering paroxetine in the third trimester. best Dosage for Elderly or Debilitated Patients, and Patients With Severe Renal or Hepatic Impairment: pill The recommended initial dose of PAXIL CR is 12.5 mg/day for elderly patients, debilitated patients, and/or patients with severe renal or hepatic impairment. Increases may be made if indicated. Dosage should not exceed 50 mg/day. Switching Patients to or From a Monoamine sales Oxidase Inhibitor: At least 14 days dose should elapse between discontinuation dosing of an MAOI and initiation price of therapy with PAXIL CR. Similarly, at least 14 days should be allowed after stopping PAXIL CR before starting an MAOI. Discontinuation cost of Treatment With PAXIL CR: Symptoms associated discontinuation of immediate-release paroxetine hydrochloride or PAXIL CR have been reported (see PRECAUTIONS). Patients should be monitored for these symptoms when discontinuing treatment, regardless of the indication for which PAXIL CR is being prescribed. A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming save the previously prescribed dose order may be considered. Subsequently, the physician may continue decreasing the dose but at a more gradual rate. HOW SUPPLIED PAXIL CR is supplied and as an enteric film-coated, controlled-release, round tablet, as follows: 12.5-mg yellow tablets, engraved with PAXIL CR and 12.5 NDC 0029-3206-13 Bottles of 30 25-mg pink tablets, engraved with PAXIL CR and 25 NDC 0029-3207-13 Bottles of 30 37.5 mg blue tablets, engraved with PAXIL CR and 37.5 NDC 0029-3208-13 Bottles free of 30 Store at or below 25ฐC (77ฐF) effectsPAXIL CR is a registered trademark of GlaxoSmithKline. GEOMATRIX is a trademark of Jago Pharma, Muttenz, Switzerland. January 2005 MG-PC:1 GlaxoSmithKline pregnancy Research Triangle Park, NC 27709 2006, GlaxoSmithKline. All rights reserved. July 2006 PC:L23 FDA date: 08/22/06 Next: Paxil-CR - Side Effects & Drug Interactions ป ซ Previous: Paxil-CR - Clinical Pharmacology ท ซ previous ท 1 ท 2 ท 3 ท 4 ท 5 ท 6 ท 7 ท next ป Health Tools from WebMD First Aid & Emergencies From allergies to sunburn, we can help. Symptom Checker To check symptoms ingredient start here. 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